Sharma J B, Gulati N, Malik S
Department of Obstetrics and Gynaecology-II, Medical College and Hospital, Rohtak, Haryana, India.
Int J Gynaecol Obstet. 1991 Mar;34(3):221-7. doi: 10.1016/0020-7292(91)90353-7.
A total of ten patients with lesions of neurofibromatosis during pregnancy were followed up for pregnancy complications. Seven cases (70%) had hypertensive disorders of pregnancy; four had severe PET (pre-eclamptic toxemia) including one case of eclampsia, one had mild PET and the other two had only mild gestational hypertension. A total of 60% had preterm labor and in none of these did the baby survive; thus perinatal mortality was 600/1000. Mean gestation was 33.0 weeks and mean birthweight was only 1.924 kg. Thus, neurofibromatosis during pregnancy is associated with poor obstetrical outcome and requires greater care.
共有10例妊娠期间患有神经纤维瘤病的患者接受了妊娠并发症随访。7例（70%）患有妊娠期高血压疾病；4例患有重度子痫前期（先兆子痫），其中1例发生子痫，1例患有轻度子痫前期，另外2例仅患有轻度妊娠期高血压。共有60%发生早产，这些早产病例中无一例婴儿存活；因此围产儿死亡率为600/1000。平均孕周为33.0周，平均出生体重仅为1.924千克。因此，妊娠期间的神经纤维瘤病与不良产科结局相关，需要更密切的护理。
