Gillin J C, Fram D H, Wyatt R J, Henkin R I, Snyder F
Psychopharmacologia. 1975;40(4):305-11. doi: 10.1007/BF00421468.
L-Histidine was administered to three patients with intractable narcolepsy (20 g/day for 2 weeks), to 4 normal volunteers (32.4 g/day for 5 days), and to a patient with progressive systemic sclerosis (48.6 g/day for 16 days). No effect was observed on noctural EEG sleep patterns in any of the subjects or on the symptoms of the patients with narcolepsy. These results fail to support the hypothesis that histamine is a waking factor.
对三名患有顽固性发作性睡病的患者（每天20克，持续2周）、四名正常志愿者（每天32.4克，持续5天）和一名进行性系统性硬化症患者（每天48.6克，持续16天）给予L-组氨酸。在任何受试者中均未观察到对夜间脑电图睡眠模式有影响，对发作性睡病患者的症状也没有影响。这些结果未能支持组胺是一种清醒因子的假说。
