Bierman C W, Maxwell D, Rytina E, Emanuel M B, Lee T H
Department of Pediatrics, University of Washington, Seattle 98105.
J Allergy Clin Immunol. 1991 May;87(5):1013-9. doi: 10.1016/0091-6749(91)90425-n.
This study is of the effect of the blockade of histamine H1 receptors by a long-acting antihistamine on the immediate and late clinical response to antigen (Ag) and on the recruitment of eosinophils in the late-phase cutaneous reaction. Ten adult volunteers with late-phase reactions to the intradermal injection of either Dermatophagoides pteronyssinus or Phleum pratense (timothy) pollen performed a double-blind, crossover study. Each volunteer took astemizole, 10 mg, or identical placebo, daily for 2 weeks. Ag in the concentration that induced a late reaction in the screening visit was injected intradermally at the end of each drug period. The early reaction was measured serially for 30 minutes and the late reaction at 4 and 6 hours. Biopsies of the Ag and control sites were also performed at 6 hours. After a 6-week washout period, subjects then took the opposite medication for 2 weeks and returned for skin testing and biopsy. Skin testing demonstrated that astemizole inhibited the immediate response to both histamine and allergen but had no effect on the late response at 4 hours and at 6 hours. Biopsy specimens revealed no significant effect on eosinophil recruitment at 6 hours. We conclude that histamine H1-receptor blockade has no effect on the late cutaneous reaction to Ag.
本研究旨在探讨长效抗组胺药对组胺H1受体的阻断作用，其对抗原（Ag）的即刻和迟发临床反应以及对迟发性皮肤反应中嗜酸性粒细胞募集的影响。10名对皮内注射粉尘螨或梯牧草（ Timothy）花粉产生迟发反应的成年志愿者进行了一项双盲交叉研究。每位志愿者每天服用10毫克阿司咪唑或相同的安慰剂，持续2周。在每个药物疗程结束时，皮内注射在筛选访视中诱导迟发反应的浓度的Ag。连续30分钟测量早期反应，并在4小时和6小时测量迟发反应。在6小时时也对Ag和对照部位进行活检。经过6周的洗脱期后，受试者再服用相反的药物2周，然后返回进行皮肤测试和活检。皮肤测试表明，阿司咪唑抑制了对组胺和变应原的即刻反应，但对4小时和6小时的迟发反应没有影响。活检标本显示在6小时时对嗜酸性粒细胞募集没有显著影响。我们得出结论，组胺H1受体阻断对Ag的迟发性皮肤反应没有影响。
