Nowak G, Zak J
Institute of Pharmacology, Polish Academy of Sciences, Krakow.
J Neurochem. 1991 Jun;56(6):2004-6. doi: 10.1111/j.1471-4159.1991.tb03459.x.
The effect of repeated treatment with electroconvulsive shock (ECS) on the turnover of cortical alpha 1-adrenoceptors in rats was measured using the N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ)-induced irreversible receptor inactivation method. Repeated treatment with ECS did not affect parameters (the synthesis rate constant r, the degradation rate constant k) of alpha 1-adrenoceptor turnover. Because increase in the density of alpha 1-adrenoceptors in the ECS-treated group disappears later during measurement of turnover, several calculation possibilities were discussed. The present data confirm that repeated treatment with ECS produces a short-lasting up-regulation of cortical alpha 1-adrenoceptors, but does not affect the turnover of this receptor type.
采用N - 乙氧羰基 - 2 - 乙氧基 - 1,2 - 二氢喹啉（EEDQ）诱导的不可逆受体失活方法，测定了反复电惊厥休克（ECS）治疗对大鼠皮质α1 - 肾上腺素能受体更新率的影响。反复ECS治疗不影响α1 - 肾上腺素能受体更新的参数（合成速率常数r、降解速率常数k）。由于在ECS治疗组中α1 - 肾上腺素能受体密度的增加在更新率测量后期消失，因此讨论了几种计算可能性。目前的数据证实，反复ECS治疗可使皮质α1 - 肾上腺素能受体产生短期上调，但不影响该受体类型的更新。
