Nowak G, Przegaliński E
Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland.
J Neural Transm. 1988;71(1):57-64. doi: 10.1007/BF01259410.
The influence of acute and repeated treatment with imipramine, amitriptyline, mianserin, citalopram and ECS on alpha 1-adrenoceptors in different structures of the rat brain (cerebral cortex, hippocampus and thalamus) was measured using [3H] prazosin as a ligand. Repeated, but not acute, treatment with all the above antidepressant drugs and ECS induced an increase in the density of alpha 1-adrenoceptors in the cerebral cortex. On the other hand, no changes were found in the hippocampus and thalamus, with an exception of the increased number of [3H] prazosin binding sites in the thalamus after imipramine. The results suggest that the up-regulation of alpha 1-adrenoceptors following repeated antidepressant treatment is not a general phenomenon within the central nervous system.
使用[3H]哌唑嗪作为配体，测定了丙咪嗪、阿米替林、米安色林、西酞普兰和电休克惊厥（ECS）急性及重复给药对大鼠脑不同结构（大脑皮层、海马和丘脑）中α1 -肾上腺素能受体的影响。上述所有抗抑郁药物及电休克惊厥重复给药（而非急性给药）均导致大脑皮层中α1 -肾上腺素能受体密度增加。另一方面，海马和丘脑中未发现变化，但丙咪嗪给药后丘脑的[3H]哌唑嗪结合位点数量增加。结果表明，重复抗抑郁治疗后α1 -肾上腺素能受体的上调并非中枢神经系统内的普遍现象。
