Department of Biochemistry, University of Oxford.
Biochem J. 1966 Dec;101(3):741-6. doi: 10.1042/bj1010741.
When the SH groups of various derivatives of human haemoglobin are converted into their mercuric mercaptides small changes are observed in the optical rotatory dispersion in the range 385-294mmu. These changes are proportionately greater for the reactive than for the unreactive SH groups. These observations have been interpreted in terms of the conformational changes that are likely to occur in the haemoglobin molecule on modification of the SH groups.
当各种人血红蛋白衍生物的 SH 基团被转化为它们的汞硫醇盐时,在 385-294nm 的旋光色散中观察到微小的变化。对于反应性的 SH 基团,这些变化比非反应性的 SH 基团更大。这些观察结果可以根据 SH 基团修饰时血红蛋白分子可能发生的构象变化来解释。