莫匹罗星鼻软膏根除慢性血液透析患者鼻腔金黄色葡萄球菌定植的疗效
Efficacy of mupirocin nasal ointment in eradicating Staphylococcus aureus nasal carriage in chronic haemodialysis patients.
作者信息
Holton D L, Nicolle L E, Diley D, Bernstein K
机构信息
Section of Infectious Diseases, University of Manitoba.
出版信息
J Hosp Infect. 1991 Feb;17(2):133-7. doi: 10.1016/0195-6701(91)90177-a.
Topical 2% mupirocin ointment eradicated chronic Staphylococcus aureus nasal carriage immediately post-therapy in 17 (77%) of 22 haemodialysis patients. Mean time to recurrence was 3.8 weeks. Similar pre-therapy and post-therapy phage types occurred in 12 (71%) of 17 patients. Staphylococcus aureus infections developed in none of 17 successfully treated patients, two of five treatment failures (P = 0.05), and 10 of 46 untreated patients studied concurrently (P = 0.03).
在22例血液透析患者中，局部使用2%莫匹罗星软膏治疗后，22例中有17例（77%）的慢性金黄色葡萄球菌鼻腔定植立即被清除。复发的平均时间为3.8周。17例患者中有12例（71%）在治疗前和治疗后的噬菌体类型相似。17例成功治疗的患者均未发生金黄色葡萄球菌感染，5例治疗失败的患者中有2例发生感染（P = 0.05），同时研究的46例未治疗患者中有10例发生感染（P = 0.03）。
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