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消毒剂及其对感染控制的影响

: Disinfectants and Implications for Infection Control.

作者信息

Ku Tsun S N, Walraven Carla J, Lee Samuel A

机构信息

Section of Infectious Disease, New Mexico VA Health Care System, Albuquerque, NM, United States.

Division of Infectious Diseases, Department of Internal Medicine, University of New Mexico Health Science Center, Albuquerque, NM, United States.

出版信息

Front Microbiol. 2018 Apr 12;9:726. doi: 10.3389/fmicb.2018.00726. eCollection 2018.

Abstract

is a rapidly emerging pathogen and is able to cause severe infections with high mortality rates. It is frequently misidentified in most clinical laboratories, thus requiring more specialized identification techniques. Furthermore, several clinical isolates have been found to be multidrug resistant and there is evidence of nosocomial transmission in outbreak fashion. Appropriate infection control measures will play a major role in controlling the management and spread of this pathogen. Unfortunately, there are very few data available on the effectiveness of disinfectants against . Chlorine-based products appear to be the most effective for environmental surface disinfection. Other disinfectants, although less effective than chlorine-based products, may have a role as adjunctive disinfectants. A cleaning protocol will also need to be established as the use of disinfectants alone may not be sufficient for maximal decontamination of patient care areas. Furthermore, there are fewer data on the effectiveness of antiseptics against for patient decolonization and hand hygiene for healthcare personnel. Chlorhexidine gluconate has shown some efficacy in studies but there are reports of patients with persistent colonization despite twice daily body washes with this disinfectant. Hand hygiene using soap and water, with or without chlorhexidine gluconate, may require the subsequent use of alcohol-based hand sanitizer for maximal disinfection. Further studies will be needed to validate the currently studied disinfectants for use in real-world settings.

摘要

是一种迅速出现的病原体,能够导致严重感染并伴有高死亡率。在大多数临床实验室中它经常被误识别,因此需要更专业的鉴定技术。此外,已发现几种临床分离株具有多重耐药性,并且有证据表明其以暴发形式在医院内传播。适当的感染控制措施将在控制这种病原体的管理和传播方面发挥主要作用。不幸的是,关于消毒剂对……有效性的数据非常少。含氯产品似乎对环境表面消毒最有效。其他消毒剂虽然不如含氯产品有效,但可能作为辅助消毒剂发挥作用。还需要制定清洁方案,因为仅使用消毒剂可能不足以对患者护理区域进行最大程度的去污。此外,关于防腐剂对……用于患者去定植和医护人员手部卫生有效性的数据较少。葡萄糖酸氯己定在……研究中已显示出一定疗效,但有报告称,尽管每天用这种消毒剂清洗身体两次,仍有患者持续定植。使用肥皂和水进行手部卫生,无论是否使用葡萄糖酸氯己定,可能随后都需要使用酒精类洗手液以实现最大程度的消毒。需要进一步研究以验证目前所研究的消毒剂在实际环境中的使用效果。

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: Disinfectants and Implications for Infection Control.消毒剂及其对感染控制的影响
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Surface disinfection challenges for Candida auris: an in-vitro study.Candida auris 的表面消毒挑战:一项体外研究。
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Candida auris: a Review of the Literature.耳念珠菌:文献复习。
Clin Microbiol Rev. 2017 Nov 15;31(1). doi: 10.1128/CMR.00029-17. Print 2018 Jan.
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Effectiveness of Disinfectants Against Candida auris and Other Candida Species.消毒剂对耳念珠菌和其他念珠菌属种的有效性。
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