Lenkei R, Björk O, Ost A, Biberfeld P
Department of Immunology, National Bacteriological Laboratory, Stockholm, Sweden.
Leuk Res. 1991;15(4):189-94. doi: 10.1016/0145-2126(91)90120-i.
Pre-B acute lymphoblastic leukemia (ALL) was diagnosed in 37 children morphologically, histochemically, and by immunophenotyping by flow cytometry. In all patients the leukemic blasts expressed HLA-DR and CD19 (Leu-12). In 10 patients 20% or more of the blast cells expressed a myeloid antigen: CD15 (Leu-M1) in seven, CD33 (My9) in two and CD13 (My7) in one patient. All 37 children achieved complete remission, but eight relapsed. Relapse occurred in six of seven patients with CD15-positive blasts, but in only two of 27 patients with CD15-negative blasts (p = 0.0003). Thus, the occurrence of CD15 on the blasts of children with pre-B ALL shows a remarkable association with a high risk of relapse, and these patients should therefore be considered to belong to the high-risk group regardless of other prognostic factors.
通过形态学、组织化学以及流式细胞术免疫表型分析，确诊37例儿童患前体B淋巴细胞白血病（ALL）。所有患者的白血病原始细胞均表达HLA-DR和CD19（Leu-12）。10例患者中，20%或更多的原始细胞表达一种髓系抗原：7例表达CD15（Leu-M1），2例表达CD33（My9），1例表达CD13（My7）。37例儿童均实现完全缓解，但8例复发。CD15阳性原始细胞的7例患者中有6例复发，而CD15阴性原始细胞的27例患者中仅2例复发（p = 0.0003）。因此，前体B-ALL儿童原始细胞上CD15的出现与高复发风险显著相关，因此，无论其他预后因素如何，这些患者均应被视为高危组。
