Cooper D N
Molecular Genetics Section, Thrombosis Research Institute, Chelsea, London, UK.
Blood Rev. 1991 Mar;5(1):55-70. doi: 10.1016/0268-960x(91)90009-2.
Inherited defects of antithrombin III, protein C, protein S, heparin cofactor II, plasminogen and the fibrinogens are thought to be responsible for between 10 and 15% of all patients presenting with recurrent venous thrombosis. The structure, function and expression of these genes and the nature of the gene lesions underlying the deficiency states are reviewed in detail.
