Audebert A, Zittoun J, Zittoun R, Bousser J
Sem Hop. 1975 Jan 20;51(4):243-5.
The authors report a case of macrocytic anemia due to folate deficiency occurring suddenly after the administration of trimethoprime-sulfamethoxazole and completely cured by folic acid. This type of complication occurs particularly often in patients who already have a relative folate deficiency. In our case only moderate alcoholism was found. Thus individual predisposition due to enzyme abnormality must be considered. Prophylactic administration of folic acid in patients receiving this drug association is thus advisable.
作者报告了1例因服用复方新诺明后突然出现叶酸缺乏所致的巨幼细胞贫血，且经叶酸完全治愈的病例。这种并发症在已有相对叶酸缺乏的患者中尤为常见。在我们的病例中，仅发现有中度酗酒情况。因此，必须考虑因酶异常导致的个体易感性。故而，建议对接受该药物组合治疗的患者预防性给予叶酸。
