Galton D J
S Afr Med J. 1975 Mar 22;49(13):469-72.
Some of the control elements required for the fine regulation of metabolic processes in the adipocyte are described. These include substrate carriers, hormone receptors, allosteric enzymes and template surfaces. A possible example of an acquired defect of a rate-determining enzyme of glycolysis in the lipoma adipocyte is described. This is manifest as an impaired sensitivity of phosphofructokinase to feedback inhibtion by citrate. The orgin and consequences of this lesion are discussed.
本文描述了脂肪细胞中代谢过程精细调节所需的一些控制元件。这些元件包括底物载体、激素受体、变构酶和模板表面。文中还描述了脂肪瘤脂肪细胞中糖酵解限速酶获得性缺陷的一个可能例子。这表现为磷酸果糖激酶对柠檬酸反馈抑制的敏感性受损。本文讨论了这种损伤的起源和后果。
