Inhibition of rabies virus infection in cultured rat cortical neurons by an N-methyl-D-aspartate noncompetitive antagonist, MK-801.
作者信息
Tsiang H, Ceccaldi P E, Ermine A, Lockhart B, Guillemer S
机构信息
Rabies Unit, Pasteur Institute, Paris, France.
出版信息
Antimicrob Agents Chemother. 1991 Mar;35(3):572-4. doi: 10.1128/AAC.35.3.572.
Abstract
A noncompetitive N-methyl-D-aspartate (NMDA) antagonist, MK-801 (0.5 to 2.0 mM), inhibits rabies virus infection in rat primary cortical neurons, whereas the competitive NMDA antagonist AP5 has no effect. The results suggest that MK-801-mediated inhibition of rabies virus replication, although selective, is not operating through the high-affinity binding site mechanism.
摘要
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