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Inhibition of rabies virus infection in cultured rat cortical neurons by an N-methyl-D-aspartate noncompetitive antagonist, MK-801.N-甲基-D-天冬氨酸非竞争性拮抗剂MK-801对培养的大鼠皮层神经元中狂犬病病毒感染的抑制作用。
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2
Comparison of the potency of competitive NMDA antagonists against the neurotoxicity of glutamate and NMDA.
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3
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Exp Neurol. 1993 Oct;123(2):204-15. doi: 10.1006/exnr.1993.1153.
4
Distinct effects of MK-801 and (+/-)-2-amino-5-phosphonopentanoic acid on N-methyl-D-aspartate-induced rise of brain temperature in rats.MK-801和（±）-2-氨基-5-磷酸戊酸对N-甲基-D-天冬氨酸诱导的大鼠脑温升高的不同作用。
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The novel anticonvulsant MK-801 binds to the activated state of the N-methyl-D-aspartate receptor in rat brain.新型抗惊厥药MK-801与大鼠脑中N-甲基-D-天冬氨酸受体的激活状态相结合。
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Sustained exposure to a glycine receptor partial agonist differentially alters NMDA receptor agonist and antagonist potencies in cultured spinal cord neurons.持续暴露于甘氨酸受体部分激动剂会差异性地改变培养脊髓神经元中NMDA受体激动剂和拮抗剂的效力。
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Regional alterations in brain amino acids after administration of the N-methyl-D-aspartate receptor antagonists MK-801 and CGP 39551 in rats.给大鼠注射 N-甲基-D-天冬氨酸受体拮抗剂 MK-801 和 CGP 39551 后脑内氨基酸的区域变化
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Effects of excitatory amino acids and their antagonists on the light response of luminosity and color-opponent horizontal cells in the turtle (Pseudemys scripta elegans) retina.兴奋性氨基酸及其拮抗剂对乌龟（秀丽锦龟）视网膜中亮度及颜色拮抗水平细胞光反应的影响。
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N-methyl-D-aspartate antagonists block fos-like protein expression induced via multiple signaling pathways in cultured cortical neurons.N-甲基-D-天冬氨酸拮抗剂可阻断培养的皮质神经元中通过多种信号通路诱导的类Fos蛋白表达。
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Neurotropism of rabies virus. An in vitro study.狂犬病病毒的嗜神经性。一项体外研究。
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Synaptic release of excitatory amino acid neurotransmitter mediates anoxic neuronal death.兴奋性氨基酸神经递质的突触释放介导缺氧性神经元死亡。
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The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate.分离麻醉药氯胺酮和苯环己哌啶可选择性降低N-甲基天冬氨酸对中枢哺乳动物神经元的兴奋作用。
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Inhibition of opiate receptor-mediated signal transmission by rabies virus in persistently infected NG-108-15 mouse neuroblastoma-rat glioma hybrid cells.狂犬病病毒对持续感染的NG-108-15小鼠神经母细胞瘤-大鼠胶质瘤杂交细胞中阿片受体介导的信号传导的抑制作用。
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Electrophysiological and sleep alterations in experimental mouse rabies.实验性小鼠狂犬病的电生理和睡眠改变
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The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.抗惊厥药物MK-801是一种有效的N-甲基-D-天冬氨酸拮抗剂。
Proc Natl Acad Sci U S A. 1986 Sep;83(18):7104-8. doi: 10.1073/pnas.83.18.7104.
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MK-801 powerfully protects against N-methyl aspartate neurotoxicity.
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MK-801 is neuroprotective in gerbils when administered during the post-ischaemic period.在沙土鼠缺血后阶段给药时，MK-801具有神经保护作用。
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Neuroprotective effects of MK-801 in vivo: selectivity and evidence for delayed degeneration mediated by NMDA receptor activation.MK-801在体内的神经保护作用：NMDA受体激活介导的延迟性变性的选择性及证据
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Non-competitive inhibition of GABA currents by phenothiazines in cultured chick spinal cord and rat hippocampal neurons.
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N-甲基-D-天冬氨酸非竞争性拮抗剂MK-801对培养的大鼠皮层神经元中狂犬病病毒感染的抑制作用。

Inhibition of rabies virus infection in cultured rat cortical neurons by an N-methyl-D-aspartate noncompetitive antagonist, MK-801.

作者信息

Tsiang H, Ceccaldi P E, Ermine A, Lockhart B, Guillemer S

机构信息

Rabies Unit, Pasteur Institute, Paris, France.

出版信息

Antimicrob Agents Chemother. 1991 Mar;35(3):572-4. doi: 10.1128/AAC.35.3.572.

DOI:10.1128/AAC.35.3.572
PMID:1674849
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC245052/
Abstract

A noncompetitive N-methyl-D-aspartate (NMDA) antagonist, MK-801 (0.5 to 2.0 mM), inhibits rabies virus infection in rat primary cortical neurons, whereas the competitive NMDA antagonist AP5 has no effect. The results suggest that MK-801-mediated inhibition of rabies virus replication, although selective, is not operating through the high-affinity binding site mechanism.

摘要

非竞争性N-甲基-D-天冬氨酸（NMDA）拮抗剂MK-801（0.5至2.0毫摩尔）可抑制大鼠原代皮质神经元中的狂犬病病毒感染，而竞争性NMDA拮抗剂AP5则无此作用。结果表明，MK-801介导的狂犬病病毒复制抑制作用虽然具有选择性，但并非通过高亲和力结合位点机制发挥作用。