N-甲基-D-天冬氨酸非竞争性拮抗剂MK-801对培养的大鼠皮层神经元中狂犬病病毒感染的抑制作用。
Inhibition of rabies virus infection in cultured rat cortical neurons by an N-methyl-D-aspartate noncompetitive antagonist, MK-801.
作者信息
Tsiang H, Ceccaldi P E, Ermine A, Lockhart B, Guillemer S
机构信息
Rabies Unit, Pasteur Institute, Paris, France.
出版信息
Antimicrob Agents Chemother. 1991 Mar;35(3):572-4. doi: 10.1128/AAC.35.3.572.
Abstract
A noncompetitive N-methyl-D-aspartate (NMDA) antagonist, MK-801 (0.5 to 2.0 mM), inhibits rabies virus infection in rat primary cortical neurons, whereas the competitive NMDA antagonist AP5 has no effect. The results suggest that MK-801-mediated inhibition of rabies virus replication, although selective, is not operating through the high-affinity binding site mechanism.
摘要
非竞争性N-甲基-D-天冬氨酸（NMDA）拮抗剂MK-801（0.5至2.0毫摩尔）可抑制大鼠原代皮质神经元中的狂犬病病毒感染，而竞争性NMDA拮抗剂AP5则无此作用。结果表明，MK-801介导的狂犬病病毒复制抑制作用虽然具有选择性，但并非通过高亲和力结合位点机制发挥作用。
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