Kolbinger W, Trepel M, Beyer C, Pilgrim C, Reisert I
Abteilung für Anatomie und Zellbiologie, Universität Ulm, F.R.G.
Brain Res. 1991 Mar 29;544(2):349-52. doi: 10.1016/0006-8993(91)90079-b.
Soma sizes of embryonic male and female tyrosine hydroxylase-immunoreactive neurons were measured in 3 diencephalic regions in situ and in diencephalic dissociated cell cultures. Male neurons were about 30% larger than female neurons both in vitro and in situ. Treatment of cultures with sex steroids did not affect the sex differences. It is concluded that sexual differentiation of dopaminergic neurons may be under primary genetic control.
在原位以及间脑解离细胞培养物中，测量了胚胎期雄性和雌性酪氨酸羟化酶免疫反应性神经元在3个间脑区域的胞体大小。无论是在体外还是原位，雄性神经元都比雌性神经元大约30%。用性类固醇处理培养物并不影响性别差异。得出的结论是，多巴胺能神经元的性别分化可能受主要基因控制。
