维生素A和D对大鼠肝脏微粒体生物合成L-抗坏血酸的影响。
Effects of vitamins A and D on the biosynthesis of L-ascorbic acid by rat-liver microsomes.
作者信息
Ghosh N C, Chatterjee I, Chatterjee G C
机构信息
Department of Applied Chemistry and Biochemistry, University Colleges of Science and Technology, Calcutta 9, India.
出版信息
Biochem J. 1965 Oct;97(1):247-9. doi: 10.1042/bj0970247.
Abstract
- The synthesis of l-ascorbic acid from either d-glucuronolactone or l-gulonolactone by liver microsomes of rats is decreased under conditions of hypervitaminosis A; under hypervitaminosis D the synthesis from d-glucuronolactone is increased and that from l-gulonolactone is not affected. 2. The microsomal conversion of l-gulonolactone into l-ascorbic acid is impaired in liver tissues of rats made deficient with respect to either vitamin A or vitamin D when compared with the controls maintained on stock diet.
摘要
- 在维生素A过多的情况下，大鼠肝脏微粒体由D - 葡糖醛酸内酯或L - 古洛糖酸内酯合成L - 抗坏血酸的能力降低；在维生素D过多的情况下，由D - 葡糖醛酸内酯的合成增加，而由L - 古洛糖酸内酯的合成不受影响。2. 与喂饲普通饲料的对照大鼠相比，维生素A或维生素D缺乏的大鼠肝脏组织中，L - 古洛糖酸内酯向L - 抗坏血酸的微粒体转化受损。
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本文引用的文献
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Effect of deficiency of vitamin B complex on the "redox" system in the eye-lens.复合维生素B缺乏对眼晶状体“氧化还原”系统的影响。
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A study of the relation between folic acid and tissue ascorbic acid.一项关于叶酸与组织中抗坏血酸之间关系的研究。
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Effect of hypervitaminosis A on hepatic ascorbic acid in the rat.维生素A过多症对大鼠肝脏中抗坏血酸的影响。
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Effect of liver necrosis and thyrotoxicosis on the synthesis of L-ascorbic acid by rat-liver microsomes.肝坏死和甲状腺毒症对大鼠肝微粒体合成L-抗坏血酸的影响。
Biochem J. 1963 Jun;87(3):536-40. doi: 10.1042/bj0870536.
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On a lipid cofactor involved in the conversion of L-gulonolactone into L-ascorbic acid.关于一种参与L-古洛糖酸转化为L-抗坏血酸过程的脂质辅因子。
Arch Biochem Biophys. 1960 Jan;86:154-5. doi: 10.1016/0003-9861(60)90384-2.
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Biological synthesis of L-ascorbic acid in animal tissues: conversion of L-gulonolactone into L-ascorbic acid.动物组织中L-抗坏血酸的生物合成：L-古洛糖酸内酯向L-抗坏血酸的转化。
Biochem J. 1960 Jan;74(1):193-203. doi: 10.1042/bj0740193.
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