Rerinck H C, Kamann S, Wollenberg A
Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität München, Frauenlobstrasse 9-11, 80337 München.
Hautarzt. 2006 Jul;57(7):586-91. doi: 10.1007/s00105-006-1168-x.
Eczema herpeticum is an acute, disseminated herpes simplex virus infection which remains a feared complication of eczematous skin diseases, especially atopic dermatitis. The vesicular and erosive clinical picture is often accompanied by systemic signs and symptoms. Why some atopic patients experience multiple attacks of eczema herpeticum and others never have the disorder remains a mystery. Patients with severe or untreated atopic dermatitis are more likely to be affected. The pathogenesis appears to involve a complex interplay of factors, including demasking of binding sites for the virus through the dermatitis, failure to up-regulate antiviral proteins and a lack of plasmacytoid dendritic cells. Treatment of choice is systemic acyclovir therapy.
疱疹样湿疹是一种急性播散性单纯疱疹病毒感染，仍然是湿疹性皮肤病（尤其是特应性皮炎）令人恐惧的并发症。水疱和糜烂的临床表现常伴有全身症状和体征。为什么一些特应性患者会多次发作疱疹样湿疹而另一些患者从未患过这种疾病仍是个谜。患有严重或未经治疗的特应性皮炎的患者更容易受到影响。其发病机制似乎涉及多种因素的复杂相互作用，包括通过皮炎使病毒结合位点暴露、未能上调抗病毒蛋白以及缺乏浆细胞样树突状细胞。治疗的首选是全身性阿昔洛韦疗法。
