de Moraes Ramos Flávia Maria, Schönlau Frank, Novaes Pedro Duarte, Manzi Flávio Ricardo, Bóscolo Frab Norberto, de Almeida Solange Maria
Oral Radiology, School of Dentistry of Piracicaba/UNICAMP, Piracicaba, São Paulo, Brazil.
Phytother Res. 2006 Aug;20(8):676-9. doi: 10.1002/ptr.1934.
X-rays and gamma radiation delivered to the abdominal region for cancer treatment encompasses severe damage to the intestinal mucosa, which significantly impairs a patient's quality of life. To a great extent the deleterious effects of x-radiation originate from radiolysis-induced reactive oxygen species. The well-researched powerful antioxidant Pycnogenol was administered orally to rats prior to x-irradiation with 15 Gy. Histological sections of the intestines showed a dramatically better condition of the mucosal layers compared with the irradiated control animals administered water without Pycnogenol. Pycnogenol treatment significantly preserved the height and number of villi as well as the glandular layer and a diminished number of congested vases were present. No intestinal alterations were seen in control animals receiving Pycnogenol in the absence of radiation. It is concluded that Pycnogenol provides significant protection from ionizing radiation damage.
用于癌症治疗的腹部区域的X射线和伽马辐射会对肠道黏膜造成严重损伤，这会显著损害患者的生活质量。在很大程度上，X射线的有害影响源于辐射分解诱导的活性氧。在对大鼠进行15 Gy的X射线照射之前，给它们口服经过充分研究的强效抗氧化剂碧萝芷。与未服用碧萝芷而只给水的受辐照对照动物相比，肠道组织切片显示黏膜层状况明显更好。碧萝芷治疗显著保留了绒毛的高度和数量以及腺体层，并且充血血管的数量减少。在未接受辐射的情况下接受碧萝芷的对照动物中未观察到肠道改变。得出的结论是，碧萝芷对电离辐射损伤提供了显著的保护作用。
