Abdu A, Adamu B, Sani M U, Mohammed A Z, Alhassan S U, Borodo M M
Department of Medicine, Aminu Kano Teaching Hospital, PMB 3452, Kano, Nigeria.
Afr J Med Med Sci. 2005 Dec;34(4):395-8.
With the establishment of kidney transplant centres in Nigeria and increase in the number of kidney transplant recipients returning home for follow up after successful transplant abroad, an increasing number of patients with post transplant complications are likely to be seen. There is the need for physicians vested with the care of these patients to be aware of the post transplant complications so that early diagnosis and effective treatment can be instituted so as to save both the patient and the allograft. Two out of seventeen renal transplant recipients followed up in our unit had post renal transplant Kaposi's sarcoma. Both were successfully treated with withdrawal of cyclosporin, reduction of other immunosuppressives and introduction of low dose Mycophenolate Mofetil (MMF). One had a course of radiotherapy followed by weekly intravenous vincristine and the other only had vincristine with complete remission of the lesions in both patients. Post transplant Kaposi's sarcoma occurs in Nigerian transplant patients and this report highlights the need for increased awareness and high index of suspicion of post transplant Kaposi's sarcoma among kidney transplant recipients.
随着尼日利亚肾脏移植中心的建立，以及在国外成功接受移植后回国进行随访的肾脏移植受者数量的增加，预计会有越来越多的移植后并发症患者前来就诊。负责照料这些患者的医生有必要了解移植后并发症，以便能够进行早期诊断和有效治疗，从而挽救患者和移植肾。在我们科室随访的17名肾移植受者中，有2人发生了肾移植后卡波西肉瘤。两人均通过停用环孢素、减少其他免疫抑制剂并引入低剂量霉酚酸酯（MMF）而成功治愈。其中一人接受了一个疗程的放疗，随后每周静脉注射长春新碱，另一人仅接受长春新碱治疗，两名患者的病变均完全缓解。移植后卡波西肉瘤在尼日利亚移植患者中出现，本报告强调了提高对肾移植受者移植后卡波西肉瘤的认识和高度怀疑指数的必要性。
