Influence of lipophilic counter ions on the transport of ionizable hydrophilic drugs.
作者信息
Neubert R, Fischer S
机构信息
Sektion Pharmazie, Martin-Luther-Universität, Halle/Saale, Germany.
出版信息
J Pharm Pharmacol. 1991 Mar;43(3):204-6. doi: 10.1111/j.2042-7158.1991.tb06667.x.
Abstract
The influence of lipophilic counter ions on the transport of the hydrophilic drugs pholedrine and bretylium across artificial lipid membranes has been studied using a permeation model system. The transport of both drugs was markedly enhanced by hexylsalicylate and by salts of fatty acids with a maximum at decanoate. The transport of pholedrine was additionally increased by bile salts such as desoxycholate.
摘要
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