强效CRTh2（DP2）受体拮抗剂的发现。
Discovery of potent CRTh2 (DP2) receptor antagonists.
作者信息
Birkinshaw Timothy N, Teague Simon J, Beech Claire, Bonnert Roger V, Hill Stephen, Patel Anil, Reakes Sara, Sanganee Hitesh, Dougall Iain G, Phillips Tim T, Salter Sylvia, Schmidt Jerzy, Arrowsmith Elizabeth C, Carrillo Juan J, Bell Fiona M, Paine Stuart W, Weaver Richard
机构信息
Department of Medicinal Chemistry, AstraZeneca R&D Charnwood, Loughborough, UK.
出版信息
Bioorg Med Chem Lett. 2006 Aug 15;16(16):4287-90. doi: 10.1016/j.bmcl.2006.05.062. Epub 2006 Jun 5.
PMID:16753296
Abstract
Starting with the weak agonist indomethacin, a series of potent, selective CRTh2 (DP(2)) antagonists have been discovered as potential treatments for asthma, allergic rhinitis and other inflammatory diseases.
摘要
从弱激动剂吲哚美辛开始，已经发现了一系列强效、选择性的CRTh2（DP(2)）拮抗剂，作为哮喘、过敏性鼻炎和其他炎症性疾病的潜在治疗药物。
Zotero 插件