Birkinshaw Timothy N, Teague Simon J, Beech Claire, Bonnert Roger V, Hill Stephen, Patel Anil, Reakes Sara, Sanganee Hitesh, Dougall Iain G, Phillips Tim T, Salter Sylvia, Schmidt Jerzy, Arrowsmith Elizabeth C, Carrillo Juan J, Bell Fiona M, Paine Stuart W, Weaver Richard
Department of Medicinal Chemistry, AstraZeneca R&D Charnwood, Loughborough, UK.
Bioorg Med Chem Lett. 2006 Aug 15;16(16):4287-90. doi: 10.1016/j.bmcl.2006.05.062. Epub 2006 Jun 5.
Starting with the weak agonist indomethacin, a series of potent, selective CRTh2 (DP(2)) antagonists have been discovered as potential treatments for asthma, allergic rhinitis and other inflammatory diseases.
从弱激动剂吲哚美辛开始，已经发现了一系列强效、选择性的CRTh2（DP(2)）拮抗剂，作为哮喘、过敏性鼻炎和其他炎症性疾病的潜在治疗药物。
