Bacon Constance G, Mittleman Murray A, Kawachi Ichiro, Giovannucci Edward, Glasser Dale B, Rimm Eric B
Department of Nutrition, Harvard School of Public Health, Channing Laboratory, 665 Huntington Avenue, Boston, MA 02115, USA.
J Urol. 2006 Jul;176(1):217-21. doi: 10.1016/S0022-5347(06)00589-1.
We examined the impact of obesity, physical activity, alcohol use and smoking on the development of erectile dysfunction.
Subjects included 22,086 United States men 40 to 75 years old in the Health Professionals Followup Study cohort who were asked to rate their erectile function for multiple periods on a questionnaire mailed in 2000. Men who reported good or very good erectile function and no major chronic disease before 1986 were included in the analyses.
Of men who were healthy and had good or very good erectile function before 1986, 17.7% reported incident erectile dysfunction during the 14-year followup. Obesity (multivariate relative risk 1.9, 95% CI 1.6-2.2 compared to men of ideal weight in 1986) and smoking (RR 1.5, 95% CI 1.3-1.7) in 1986 were associated with an increased risk of erectile dysfunction, while physical activity (RR 0.7, 95% CI 0.7-0.8 comparing highest to lowest quintile of physical activity) was associated with a decreased risk of erectile dysfunction. For men in whom prostate cancer developed during followup, smoking (RR 1.4, 95% CI 1.0-1.9) was the only lifestyle factor associated with erectile dysfunction.
Reducing the risk of erectile dysfunction may be a useful and to this point unexploited motivation for men to engage in health promoting behaviors. We found that obesity and smoking were positively associated, and physical activity was inversely associated with the risk of erectile dysfunction developing.
我们研究了肥胖、体育活动、饮酒和吸烟对勃起功能障碍发生的影响。
研究对象包括健康专业人员随访研究队列中的22086名40至75岁的美国男性，他们被要求在2000年邮寄的问卷中对多个时间段的勃起功能进行评分。分析纳入了在1986年之前报告勃起功能良好或非常好且无重大慢性病的男性。
在1986年时健康且勃起功能良好或非常好的男性中，17.7%在14年随访期间报告发生了勃起功能障碍。1986年时肥胖（多变量相对风险1.9，与1986年体重正常的男性相比，95%可信区间为1.6 - 2.2）和吸烟（相对风险1.5，95%可信区间为1.3 - 1.7）与勃起功能障碍风险增加相关，而体育活动（将体育活动最高五分位数与最低五分位数相比，相对风险0.7，95%可信区间为0.7 - 0.8）与勃起功能障碍风险降低相关。对于随访期间患前列腺癌的男性，吸烟（相对风险1.4，95%可信区间为1.0 - 1.9）是与勃起功能障碍相关的唯一生活方式因素。
降低勃起功能障碍风险可能是促使男性参与健康促进行为的一个有用且迄今未被利用的动机。我们发现肥胖和吸烟与勃起功能障碍风险呈正相关，而体育活动与勃起功能障碍风险呈负相关。
