Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Department of Pulmonary and Critical Care Medicine, The Lu 'an People's Hospital of Anhui Province, The Lu 'an Hospital Affiliated to Anhui Medical University, Lu 'an, China.
Nutr J. 2024 May 17;23(1):54. doi: 10.1186/s12937-024-00956-y.
Erectile dysfunction (ED) is a prevalent condition that is thought to be significantly impacted by oxidative stress. The oxidative balance score (OBS) has been built to characterize the state of antioxidant/pro-oxidant balance. There is less known regarding the relationship of OBS with ED.
This study conducted cross-sectional analyses on 1860 males who participated in the National Health and Nutrition Examination Survey (NHANES) from 2001 to 2004. OBS was constructed by the 16 dietary components and 4 lifestyle factors. Self-reported ED was defined as men who indicated that they "never" or "sometimes" could achieve or keeping an erection adequate for satisfactory intercourse. Multivariate logistic regression models were applied to examine the association between OBS and the risk of ED.
Among 1860 participants, the median OBS was 20 (IQR 15-26), and OBS was lower in males with ED vs. those without ED (P = 0.001). The results of our analyses indicated a negative correlation between OBS and ED among male subjects. Specifically, each one-unit increase in the continuous OBS was relate to 3% reduction in the odds of ED after full adjustment. Moreover, when extreme OBS quartiles were compared, the adjusted odds ratio (95% confidence interval) for the 4th OBS category was 0.53 (0.32 to 0.88) after full adjustment (P for trend < 0.05). There was also statistical significance in the relationships between dietary/lifestyle OBS with ED, and the association between lifestyle OBS and ED may be even tighter. For each unit increase in lifestyle OBS, the odds of ED decreased by 11% after full adjustment.
Higher OBS was associated with reduced risk of ED in U.S. males. These findings suggested that adopting an antioxidant-rich diet and engaging in antioxidant-promoting lifestyle behaviors may contribute to a lower incidence of ED. These results provided recommendations for a comprehensive dietary and lifestyle antioxidants for ED patients.
勃起功能障碍（ED）是一种普遍存在的病症，据认为其受到氧化应激的显著影响。氧化平衡评分（OBS）旨在描述抗氧化剂/促氧化剂平衡状态。关于 OBS 与 ED 的关系，我们了解得还比较少。
本研究对 1860 名男性进行了横断面分析，这些男性参加了 2001 年至 2004 年期间的国家健康和营养检查调查（NHANES）。OBS 是通过 16 种饮食成分和 4 种生活方式因素构建的。自我报告的 ED 定义为男性表示他们“从未”或“有时”能够实现或保持足以进行满意性交的勃起。应用多变量逻辑回归模型来检验 OBS 与 ED 风险之间的关联。
在 1860 名参与者中，中位数 OBS 为 20（IQR 15-26），患有 ED 的男性的 OBS 低于没有 ED 的男性（P=0.001）。我们的分析结果表明，OBS 与男性受试者的 ED 之间存在负相关。具体而言，OBS 连续增加一个单位，ED 的可能性降低 3%，经过完全调整后。此外，当比较极端的 OBS 四分位数时，经过完全调整后，第 4 个 OBS 类别的调整后比值比（95%置信区间）为 0.53（0.32 至 0.88）（P<0.05）。饮食/生活方式 OBS 与 ED 之间也存在统计学意义，而生活方式 OBS 与 ED 之间的关联可能更紧密。经过完全调整后，生活方式 OBS 每增加一个单位，ED 的可能性就会降低 11%。
美国男性的 OBS 越高，患 ED 的风险越低。这些发现表明，采用富含抗氧化剂的饮食和促进抗氧化剂的生活方式行为可能有助于降低 ED 的发病率。这些结果为 ED 患者提供了全面的饮食和生活方式抗氧化剂建议。
