Clague Michael J, Hammond Dean E
Physiological Laboratory, University of Liverpool, Crown Street, Liverpool L69 3BX, UK.
Curr Biol. 2006 Jun 6;16(11):R416-8. doi: 10.1016/j.cub.2006.05.009.
Recent work shows that specific adaptor interactions may sort receptors into distinct cohorts of clathrin-coated vesicles. These different vesicle populations deliver cargo to sorting endosomes of differing motilities and maturation rates, thereby determining the probability of receptor recycling and the duration of endosomal signaling.