Wink Margot H, Wijkstra Hessel, De La Rosette Jean J M C H, Grimbergen Cornelis A
Department of Urology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Minim Invasive Ther Allied Technol. 2006;15(2):93-100. doi: 10.1080/13645700600674252.
Microbubble contrast media are used to enhance ultrasound images. Because ultrasound is a real-time investigation, contrast-enhanced ultrasound offers possibilities for perfusion imaging. This review is conducted to evaluate the safety of contrast-enhanced ultrasound and its possible role in medical imaging. The safety of diagnostic ultrasound is still an important field of research. The wanted and unwanted effects of ultrasound and microbubble contrast media as well as the effects of ultrasound on these microbubbles are described. Furthermore, some of the possible applications and indications of contrast-enhanced ultrasound will be discussed. The shared advantages of MRI and ultrasound are the use of non-ionizing radiation and non-nephrotoxic contrast media. From this review it can be concluded that, for certain indications, contrast enhanced ultrasound could be a safe alternative to MRI and a valuable addition to medical imaging.
微泡造影剂用于增强超声图像。由于超声是一种实时检查方法，超声造影为灌注成像提供了可能。本综述旨在评估超声造影的安全性及其在医学成像中的潜在作用。诊断超声的安全性仍是一个重要的研究领域。文中描述了超声和微泡造影剂的预期及非预期效应，以及超声对这些微泡的影响。此外，还将讨论超声造影的一些可能应用和适应症。磁共振成像（MRI）和超声的共同优点是使用非电离辐射和非肾毒性造影剂。从本综述可以得出结论，对于某些适应症，超声造影可能是MRI的安全替代方法，也是医学成像的一项有价值的补充。
