Bokodi G, Derzbach L, Bányász I, Tulassay T, Vásárhelyi B
First Department of Pediatrics, Semmelweis University, Budapest, Hungary.
Arch Dis Child Fetal Neonatal Ed. 2007 Jan;92(1):F25-9. doi: 10.1136/adc.2005.086421. Epub 2006 Jun 5.
Data support the role of interferon (IFN)gamma and interleukin (IL)12 in perinatal complications. IFNgamma T(+874)A and IL12 p40 promoter CTCTAA/GC polymorphisms may have an effect on cytokine production.
DNA was extracted from dried blood samples of 153 low birthweight (LBW) infants and 172 healthy term infants. IFNgamma and IL12 genetic polymorphisms were determined to investigate the association between polymorphisms and ventilation characteristics, bronchopulmonary dysplasia (BPD) and other perinatal disorders.
The IFNgamma(+874)A allele was over-represented in LBW infants. Carriers of the IFNgamma(+874)T allele required mechanical ventilation and oxygen supplementation for time periods 41% and 35%, respectively, shorter than those required by those not carrying the IFNgamma(+874)T allele. Stepwise logistic regression analysis showed that carriers of the IFNgamma(+874)T allele were protected against BPD (odds ratio (OR) 0.35 (95% confidence interval (CI) (0.12 to 0.99))) and patent ductus arteriosus (OR 0.43 (95% CI 0.19 to 0.97)), whereas carriers of the IFNgamma(+874)A allele were at higher risk of severe hypotension (OR 3.40 (95% CI 1.01 to 11.52)) and respiratory distress syndrome (OR 4.03 (95% CI 1.30 to 12.50)). Carriers of the IL12 GC allele were protected against pneumonia (OR 0.32 (95% CI 0.14 to 0.75)). Carriers of the IL12 CTCTAA allele were at higher risk of developing necrotising enterocolitis (NEC; OR 2.37 (95% CI 1.01 to 5.53)).
Carrier state of the IFNgamma(+874)A allele presents an increased risk for premature birth and lung damage, as well as other perinatal complications. The risks of pneumonia and NEC are higher in heterozygotic carriers of the IL12 CTCTAA/GC polymorphism. Further studies are needed to determine whether these associations are the result of altered cytokine-producing capacity in infants carrying the tested alleles.
数据支持干扰素（IFN）γ和白细胞介素（IL）12在围产期并发症中的作用。IFNγ T(+874)A和IL12 p40启动子CTCTAA/GC多态性可能会影响细胞因子的产生。
从153例低出生体重（LBW）婴儿和172例足月健康婴儿的干血样本中提取DNA。测定IFNγ和IL12基因多态性，以研究多态性与通气特征、支气管肺发育不良（BPD）及其他围产期疾病之间的关联。
IFNγ(+874)A等位基因在LBW婴儿中过度表达。携带IFNγ(+874)T等位基因的婴儿进行机械通气和吸氧的时间分别比未携带该等位基因的婴儿短41%和35%。逐步逻辑回归分析表明，携带IFNγ(+874)T等位基因的婴儿可预防BPD（优势比（OR）0.35（95%置信区间（CI）（0.12至0.99）））和动脉导管未闭（OR 0.43（95%CI 0.19至0.97）），而携带IFNγ(+874)A等位基因的婴儿发生严重低血压（OR 3.40（95%CI 1.01至11.52））和呼吸窘迫综合征（OR 4.03（95%CI 1.30至12.50））的风险更高。携带IL12 GC等位基因的婴儿可预防肺炎（OR 0.32（95%CI 0.14至0.75））。携带IL12 CTCTAA等位基因的婴儿发生坏死性小肠结肠炎（NEC）的风险更高（OR 2.37（95%CI 1.01至5.53））。
IFNγ(+874)A等位基因的携带状态会增加早产、肺损伤及其他围产期并发症的风险。IL12 CTCTAA/GC多态性杂合子携带者发生肺炎和NEC的风险更高。需要进一步研究以确定这些关联是否是携带检测等位基因的婴儿细胞因子产生能力改变的结果。
