Lazzareschi Ilaria, Barone Giuseppe, Ruggiero Antonio, Liotti Lucia, Maurizi Palma, Larocca Luigi Maria, Riccardi Riccardo
Division of Paediatric Oncology, Department of Paediatric Sciences, Catholic University, Rome.
Pediatr Blood Cancer. 2008 Jan;50(1):119-23. doi: 10.1002/pbc.20918.
Kikuchi-Fujimoto disease (KFD) is a rare and benign disease that typically affects the cervical lymph nodes. Its aetiology is unknown and a role of the autoimmune system in the pathogenesis is hypothesized. This self-limiting disease is often confused with malignancies. No specific management is generally required but long-term follow-up should be planned despite the low risk of recurrence, as recurrences have been described many years after the first episode and there is a high risk of development of an autoimmune disease or even lymphoma. We review the clinical and histological features of KFD and report an unusual case presenting with cervical and supraclavicular lymphadenopathy, and persistent fever.
菊池-藤本病（KFD）是一种罕见的良性疾病，通常累及颈部淋巴结。其病因不明，推测自身免疫系统在发病机制中起作用。这种自限性疾病常被误诊为恶性肿瘤。一般无需特殊治疗，但尽管复发风险较低，仍应安排长期随访，因为有首次发病多年后复发的报道，且存在发展为自身免疫性疾病甚至淋巴瘤的高风险。我们回顾了菊池-藤本病的临床和组织学特征，并报告了一例表现为颈部和锁骨上淋巴结肿大及持续发热的罕见病例。
