Shman T V, Belevtsev M V, Buglova S E
Vopr Onkol. 2005;51(5):558-62.
Drug sensitivity of tumor cells was studied in 154 children diagnosed with acute leukemia. Cellular sensitivity in acute lymphoblastic leukemia (ALL) was higher than in acute myeloid one (AML), while T-line ALL cells were more sensitive to dexamethasone than those of B-line. It was suggested that lower drug sensitivity of ALL cells at the earlier stages of cell differentiation was due to their reduced susceptibility to apoptosis. Among AML cells, M3 variant was less sensitive to cytozar while M4 - to vepeside. Reduced sensitivity to vincristine was found in series M3 > M1 - M2 > M4 while that to L-asparaginase was in M1- M2 > M4 > M3.
对154例诊断为急性白血病的儿童进行了肿瘤细胞药敏研究。急性淋巴细胞白血病（ALL）的细胞敏感性高于急性髓细胞白血病（AML），而T系ALL细胞对地塞米松的敏感性高于B系。提示ALL细胞在细胞分化早期药物敏感性较低是由于其对凋亡的易感性降低。在AML细胞中，M3亚型对阿糖胞苷敏感性较低，而M4亚型对依托泊苷敏感性较低。发现对长春新碱的敏感性在M3>M1 - M2>M4系列中降低，而对L-天冬酰胺酶的敏感性在M1 - M2>M4>M3中降低。
