Murav'eva E V, Anokhin K V
Zh Vyssh Nerv Deiat Im I P Pavlova. 2006 Mar-Apr;56(2):274-81.
We have studied the role of protein synthesis in reconsolidation of memory, activated by reminder at different time period after initial acquisition. Mice were trained in a single-trial fear conditioning task and then subjected to reminder, preceded by injection of protein synthesis inhibitor cycloheximide. It was found that this procedure impaired later memory retrieval if applied at 3, 6 and 24 h as well as 14 and 30 days after initial training. This data suggests that reactivated memory is followed by protein synthesis-dependent reconsolidation both at short (3-6 h) and long (14-30 days) intervals after initial acquisition.
我们研究了蛋白质合成在记忆再巩固中的作用，这种再巩固是由初次习得后不同时间段的提示所激活的。小鼠接受单次试验恐惧条件反射任务训练，然后在注射蛋白质合成抑制剂环己酰亚胺后接受提示。结果发现，如果在初次训练后的3小时、6小时、24小时以及14天和30天应用该程序，会损害后期的记忆提取。这些数据表明，在初次习得后的短时间（3 - 6小时）和长时间（14 - 30天）间隔内，重新激活的记忆之后都会发生依赖蛋白质合成的再巩固。
