Marshall Mark R
Middlemore Hospital, Auckland, New Zealand.
Nephrology (Carlton). 2006 Jun;11(3):181-91. doi: 10.1111/j.1440-1797.2006.00581.x.
The dosing and quantification of acute renal replacement therapy has emerged as one of the most pressing issues in the management of critically-ill patients with acute kidney injury. Although there is ongoing debate as to the best marker of uraemic injury in this setting, several landmark studies have identified clearance-related expressions of acute renal replacement therapy dose as important determinants of survival. Part 1 of this review examined the factors affecting the delivery of prescribed acute renal replacement therapy dose. Part 2 summarises and contextualises findings from recent dose-outcome studies, and reviews clinical tools to assist in the prescription and quantification of acute renal replacement therapy dose.
急性肾替代治疗的剂量确定和量化已成为急性肾损伤危重症患者管理中最紧迫的问题之一。尽管对于这种情况下尿毒症损伤的最佳标志物仍存在争议，但多项具有里程碑意义的研究已确定，急性肾替代治疗剂量的清除率相关指标是生存的重要决定因素。本综述的第1部分探讨了影响规定的急性肾替代治疗剂量输送的因素。第2部分总结并结合了近期剂量-结局研究的结果，并回顾了有助于急性肾替代治疗剂量处方和量化的临床工具。
