Current status of dosing and quantification of acute renal replacement therapy. Part 2: dosing paradigms and clinical implementation.

The dosing and quantification of acute renal replacement therapy has emerged as one of the most pressing issues in the management of critically-ill patients with acute kidney injury. Although there is ongoing debate as to the best marker of uraemic injury in this setting, several landmark studies have identified clearance-related expressions of acute renal replacement therapy dose as important determinants of survival. Part 1 of this review examined the factors affecting the delivery of prescribed acute renal replacement therapy dose. Part 2 summarises and contextualises findings from recent dose-outcome studies, and reviews clinical tools to assist in the prescription and quantification of acute renal replacement therapy dose.