Monteiro Rosário, de Castro Paulo M S T, Calhau Conceição, Azevedo Isabel
Department of Biochemistry (U38/FCT), Faculty of Medicine, University of Porto, Portugal.
Obes Surg. 2006 Jun;16(6):804-6. doi: 10.1381/096089206777346600.
Obesity constitutes a serious health problem. Inflammation, which has recently been shown to follow adipocyte death, is at the basis of a series of pathogenic complications of obesity. Here we demonstrate, through modelling using the finite element method, that the bigger the adipocyte, the more fragile it becomes to rupture when submitted to common physical forces. This indicates that adipocyte size is an important determinant of cell death. Interventions to prevent adipocyte hypertrophy may, therefore, help to reduce the risk associated with obesity.
肥胖是一个严重的健康问题。炎症最近被证明是伴随脂肪细胞死亡而产生的，它是肥胖一系列致病并发症的基础。在这里，我们通过使用有限元方法进行建模证明，脂肪细胞越大，在受到常见物理力作用时就越容易破裂。这表明脂肪细胞大小是细胞死亡的一个重要决定因素。因此，预防脂肪细胞肥大的干预措施可能有助于降低与肥胖相关的风险。
