Gil-Bazo Ignacio, Páramo José Antonio, García-Foncillas Jesús
Departamento de Oncología, Clínica Universitaria, Universidad de Navarra, Pamplona, Navarra, España.
Med Clin (Barc). 2006 Apr 15;126(14):541-8. doi: 10.1157/13087141.
Cancer patients often show a clinical tendency to thromboembolic events. This tendency is due to tumor cell-related factors together with the damage of the vascular endothelial exerted by chemotherapy treatment. Gastrointestinal tumors especially contribute to these types of events. More recently, the implication of tumor angiogenesis in clotting/fibrynolisys and plasminogen systems activation has been addressed in cancer patients. Finally, some hemostasis and angiogenesis-related factors such as platelets, von Willebrand factor, fibrinogen, plasminogen activator inhibitor type-1, D dimer, and vascular endotelial growth factor have been highlighted as new potential response and survival predictors in colorectal cancer patients. In this review article, the current evidence supporting the use of these proteins in assessing prognosis in colorectal cancer patients is critically exposed and discussed.
癌症患者常常表现出发生血栓栓塞事件的临床倾向。这种倾向是由肿瘤细胞相关因素以及化疗对血管内皮造成的损伤共同导致的。胃肠道肿瘤尤其容易引发这类事件。最近，肿瘤血管生成在凝血/纤维蛋白溶解和纤溶酶原系统激活中的作用在癌症患者中已得到探讨。最后，一些与止血和血管生成相关的因子，如血小板、血管性血友病因子、纤维蛋白原、1型纤溶酶原激活物抑制剂、D-二聚体和血管内皮生长因子，已被视为结直肠癌患者新的潜在反应和生存预测指标。在这篇综述文章中，对支持使用这些蛋白质评估结直肠癌患者预后的现有证据进行了批判性的阐述和讨论。
