肾移植术后淋巴囊肿：免疫抑制治疗的影响

Lymphocele after renal transplantation: the influence of the immunosuppressive therapy.

作者信息

Tondolo V, Citterio F, Massa A, Salerno M P, Romagnoli J, Nanni G, Castagneto M

机构信息

Department of Surgery, Organ Transplantation, Catholic University, Rome, Italy.

出版信息

Transplant Proc. 2006 May;38(4):1051-2. doi: 10.1016/j.transproceed.2006.03.013.

DOI:10.1016/j.transproceed.2006.03.013

PMID:16757261

Abstract

Lymphocele is a complication of renal transplantation, representing a lymphatic collection around the grafted kidney. The use of the immunosuppressive agent sirolimus (SRL) has been associated with a significant increase in lymphocele formation. This complication has been related to the antiproliferative activity of SRL, which delays surgical wound repair and closure of injured lymphatic vessels. The aim of this study was to relate the incidence of lymphocele with immunosuppression among 158 renal transplant patients operated with routine closure of all the visible lymphatic vessels around the iliac vessels and at the renal hilum. The incidence of lymphocele was not significantly different among the various immunosuppressive regimens.

摘要

淋巴囊肿是肾移植的一种并发症，表现为移植肾周围的淋巴液聚集。免疫抑制剂西罗莫司（SRL）的使用与淋巴囊肿形成的显著增加有关。这种并发症与SRL的抗增殖活性有关，它会延迟手术伤口修复和受损淋巴管的闭合。本研究的目的是在158例肾移植患者中，探讨在常规闭合髂血管和肾门周围所有可见淋巴管的手术中，淋巴囊肿的发生率与免疫抑制之间的关系。不同免疫抑制方案之间淋巴囊肿的发生率没有显著差异。