肝细胞移植的历史概况。

Historical aspects of hepatocyte transplantation.

作者信息

Bruzzone P, Strom S C

机构信息

Department of Surgery and Transplantation Paride Stefanini, University of Rome La Sapienza, Italy.

出版信息

Transplant Proc. 2006 May;38(4):1179-80. doi: 10.1016/j.transproceed.2006.02.138.

DOI:10.1016/j.transproceed.2006.02.138

PMID:16757299

Abstract

Hepatocyte transplantation has been used for temporary metabolic support of patients in end-stage liver failure awaiting whole organ transplantation as a method to support liver function and facilitate regeneration of the native liver in cases of fulminant hepatic failure and as a "cellular therapy" for patients with genetic defects in vital liver functions. The aim of this paper was to discuss the basic research that led to clinical hepatocyte transplantation, the published clinical experience with this experimental technique, and some possible future uses of hepatocyte transplantation.

摘要

肝细胞移植已被用于为等待全器官移植的终末期肝衰竭患者提供临时代谢支持，作为支持肝功能的一种方法，并在暴发性肝衰竭病例中促进原生肝脏的再生，还作为对具有重要肝功能遗传缺陷患者的一种“细胞疗法”。本文的目的是讨论促成临床肝细胞移植的基础研究、已发表的关于这一实验技术的临床经验以及肝细胞移植未来一些可能的用途。