Vos Michele D, Clark Geoffrey J
Department of Cell and Cancer Biology, National Cancer Institutes, Rockville, Maryland, USA.
Methods Enzymol. 2006;407:311-22. doi: 10.1016/S0076-6879(05)07026-6.
There are six members of the RASSF gene family, with RASSF1 being the best characterized. All six genes produce proteins that contain Ras Association (RA) domains that can interact directly with activated Ras in overexpression studies. Their role in mediating the biological effects of Ras remains under investigation. However, they seem to modulate some of the growth inhibitory responses mediated by Ras. Moreover, evidence is accumulating that RASSF family members may serve as tumor suppressors that succumb to inactivation during the evolution of the transformed phenotype. Thus, RASSF proteins may be described as effector/tumor suppressors, in contrast to traditional Ras effectors such as Raf and PI-3 kinase, which may be considered to be effector/oncoproteins.
RASSF基因家族有六个成员，其中RASSF1的特征最为明确。在过表达研究中，所有六个基因产生的蛋白质都含有能够与活化的Ras直接相互作用的Ras关联（RA）结构域。它们在介导Ras的生物学效应中的作用仍在研究中。然而，它们似乎能调节由Ras介导的一些生长抑制反应。此外，越来越多的证据表明，RASSF家族成员可能作为肿瘤抑制因子，在转化表型的演变过程中失活。因此，与传统的Ras效应因子如Raf和PI-3激酶（可被认为是效应因子/癌蛋白）相比，RASSF蛋白可被描述为效应因子/肿瘤抑制因子。
