Quesada Humberto, Ramos-Onsins Sebastián E, Rozas Julio, Aguadé Montserrat
Mol Biol Evol. 2006 Sep;23(9):1643-7. doi: 10.1093/molbev/msl031. Epub 2006 Jun 6.
Coalescent simulations were used to investigate the possible role of population subdivision and history in shaping nucleotide variation in a recombining 88-kb genomic fragment of Drosophila simulans displaying an unusual large-scale haplotype structure. The multilocus analysis, based on summary statistics using specific demographic null models under recombination, indicates that the observed levels of linkage disequilibrium differed significantly from the values expected under different bottleneck and population admixture scenarios. These results indicate that demography alone may not account for the observed pattern of variation and support the previous claim that the data are better described by a model in which an adaptive mutation has not yet gone to fixation.
利用溯祖模拟来研究种群细分和历史在塑造拟暗果蝇一个88 kb重组基因组片段核苷酸变异方面可能发挥的作用，该片段呈现出异常的大规模单倍型结构。基于在重组情况下使用特定群体统计学无效模型的汇总统计数据进行的多位点分析表明，观察到的连锁不平衡水平与不同瓶颈和种群混合情景下预期的值存在显著差异。这些结果表明，仅靠种群统计学可能无法解释观察到的变异模式，并支持了之前的观点，即这些数据用一个适应性突变尚未固定的模型来描述会更好。
