Gratwohl A, Baldomero H, Frauendorfer K, Urbano-Ispizua A
Division of Hematology, Department of Internal Medicine, University Hospital Basel, Petersgraben 4, CH-4021 Basel, Switzerland.
Bone Marrow Transplant. 2006 Jun;37(12):1069-85. doi: 10.1038/sj.bmt.1705377.
This fifteenth annual European Group for Blood and Marrow Transplantation activity report lists the transplant activity in Europe in 2004 and documents the changes in indication over the past 15 years. In 2004, there were 22 216 first hematopoetic stem cells (HSCT), 7407 allogeneic (33%), 14 809 autologous (67%) and 4378 additional re- or multiple transplants reported from 592 centres in 38 European and five affiliated countries. Main indications were leukemias (7045 (32%; 78% allogeneic)); lymphomas (12 310 (55%; 94% autologous)); solid tumors (1759 (8%; 93% autologous)) and nonmalignant disorders (1015 (5%; 92% allogeneic)). In comparison, 145 teams from 20 countries performed 4234 HSCT (2137 allogeneic, 50%; 2097 autologous, 50%) in 1990. The overall increase was accompanied by major changes. Stem cell source changed from bone marrow to peripheral blood. More than one-third of allogeneic HSCT are now from unrelated donors. Reduced intensity conditioning is employed for one-third of allogeneic HSCT. Leukemias for allogeneic and lymphoproliferative disorders for autologous HSCT continue to increase. The decline in HSCT for chronic myeloid leukemia appears to level off for the first time since 1999. These data are informative for patient counselling and decision making for health care professionals.
这份欧洲血液与骨髓移植组第15份年度活动报告列出了2004年欧洲的移植活动，并记录了过去15年中适应证的变化。2004年，来自欧洲38个国家和5个附属国的592个中心报告了22216例首次造血干细胞移植（HSCT），其中7407例为异基因移植（33%），14809例为自体移植（67%），另有4378例再次或多次移植。主要适应证为白血病（7045例（32%；异基因移植占78%））、淋巴瘤（12310例（55%；自体移植占94%））、实体瘤（1759例（8%；自体移植占93%））和非恶性疾病（1015例（5%；异基因移植占92%））。相比之下，1990年来自20个国家的145个团队进行了4234例HSCT（2137例异基因移植，占50%；2097例自体移植，占50%）。总体增长伴随着重大变化。干细胞来源从骨髓转变为外周血。现在超过三分之一的异基因HSCT来自无关供者。三分之一的异基因HSCT采用了减低强度预处理。异基因HSCT治疗白血病和自体HSCT治疗淋巴增殖性疾病的病例数持续增加。慢性粒细胞白血病HSCT的下降自1999年以来似乎首次趋于平稳。这些数据为医疗保健专业人员进行患者咨询和决策提供了参考。
