西替利嗪二盐酸盐对嗜酸性粒细胞迁移的抑制作用及其与H1受体阻断的关系。

The inhibiting effect of cetirizine 2 HC1 on eosinophil migration and its link to H1 blockade.

作者信息

Rihoux J P

机构信息

International Product Development Department UCB S.A Chemin du Foriest, Braine l'Alleud, Belgium.

出版信息

Agents Actions Suppl. 1991;33:409-15. doi: 10.1007/978-3-0348-7309-3_31.

DOI:10.1007/978-3-0348-7309-3_31

PMID:1675836

Abstract

Since the demonstration of an inhibiting effect of cetirizine on an antigen induced eosinophils' migration in the skin of atopic subjects, a series of in vitro and in vivo studies were performed in order to clarify the mechanism of action of this new H1-blocker. The studies used FMLP and PAF as agonists, and BN 52021, dexchlorpheniramine, terfenadine and loratadine as reference compounds. The results suggest that the inhibiting effect of cetirizine on the eosinophils' migration is independent of its specific H1 blocking activity.

摘要

自从证明西替利嗪对特应性受试者皮肤中抗原诱导的嗜酸性粒细胞迁移具有抑制作用以来，进行了一系列体外和体内研究，以阐明这种新型H1阻滞剂的作用机制。这些研究使用FMLP和PAF作为激动剂，BN 52021、右氯苯那敏、特非那定和氯雷他定作为参考化合物。结果表明，西替利嗪对嗜酸性粒细胞迁移的抑制作用与其特异性H1阻断活性无关。