Moojen Vânia K M, Martins Márcio Rodrigo, Reinke Adalisa, Feier Gustavo, Agostinho Fabiano R, Cechin Edson M, Quevedo João
Laboratório de Neurociências, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil.
Neurochem Res. 2006 Apr;31(4):571-7. doi: 10.1007/s11064-006-9050-x. Epub 2006 May 9.
Serotonin (5-HT) and noradrenaline (NA) are involved in both pathogenesis and recovery from depression and anxiety. We examined the effects of acute and chronic treatment with milnacipran, a serotonin/noradrenaline reuptake inhibitors (SNRIs) antidepressant, on anxiety and memory retention in rats. Male Wistar rats received acute or chronic administration of milnacipran (12.5, 25 or 50 mg/kg) or saline (control group). The animals were separately submitted to elevated plus-maze, inhibitory avoidance and open-field tasks 1 h after injection, in the acute group, or 23 h after last injection, in the chronic group. Our results showed an anxiolytic-like effect after chronic administration of milnacipran at doses of 25 and 50 mg/kg. The treatment does not interfere in memory retention and habituation to a novel environment at any doses studied. These findings support that milnacipran, an established SNRIs antidepressant, can also be useful in the treatment of anxiety disorders.
血清素（5-羟色胺，5-HT）和去甲肾上腺素（NA）与抑郁症和焦虑症的发病机制及康复均有关联。我们研究了米那普明（一种血清素/去甲肾上腺素再摄取抑制剂，SNRIs类抗抑郁药）的急性和慢性治疗对大鼠焦虑及记忆保持的影响。雄性Wistar大鼠接受米那普明（12.5、25或50mg/kg）或生理盐水（对照组）的急性或慢性给药。急性给药组在注射后1小时，慢性给药组在末次注射后23小时，分别将动物置于高架十字迷宫、抑制性回避和旷场实验中。我们的结果显示，慢性给予25mg/kg和50mg/kg剂量的米那普明后有抗焦虑样效应。在所研究的任何剂量下，该治疗均不影响记忆保持及对新环境的习惯化。这些发现支持，已证实的SNRIs类抗抑郁药米那普明也可用于治疗焦虑症。
