Sinha U S, Kapoor A K, Singh A K, Gupta A, Mehrotra Ravi
The Department of Forensic Medicine, Moti Lal Nehru Medical College, Allahabad.
Indian J Pathol Microbiol. 2005 Apr;48(2):177-80.
Of a total of 205 poisoning deaths in our hospital in 2003, 83 cases were due to Aluminium phosphide poisoning and were further analyzed. Most vulnerable age group was 21-40 years and M:F ratio was 2:1. On naked eye examination, almost all the vital organs were found to be congested. On microscopic study, the liver showed central venous congestion, degeneration, haemorrhage, sinusoidal dilation, bile stasis, centrilobular necrosis, Kupffer cell hyperplasia, infiltration by mononuclear cells and fatty change. Microscopy of the lungs revealed alveolar thickening, oedema, dilated capillaries, collapsed alveoli and haemorrhage. In the kidney, changes were degeneration, infiltration, tubular dilation and cloudy swelling. Changes in the brain included congestion and coagulative necrosis and in the stomach, congestion and haemorrhage. Easy availability of this cheap and highly toxic substance was responsible for the sudden spurt of poisoning with aluminium phosphide.
2003年我院共有205例中毒死亡病例，其中83例死于磷化铝中毒，并对这些病例进行了进一步分析。最易中毒的年龄组为21至40岁，男女比例为2:1。肉眼检查发现，几乎所有重要器官均有充血现象。显微镜检查显示，肝脏出现中央静脉充血、变性、出血、肝血窦扩张、胆汁淤积、小叶中心坏死、库普弗细胞增生、单核细胞浸润以及脂肪变性。肺部显微镜检查显示肺泡增厚、水肿、毛细血管扩张、肺泡塌陷和出血。肾脏的变化包括变性、浸润、肾小管扩张和混浊肿胀。脑部变化为充血和凝固性坏死，胃部则有充血和出血。这种廉价且剧毒物质的容易获取导致了磷化铝中毒事件的突然激增。
