Hryckiewicz Katarzyna, Juszczyk Jacek, Samet Alfred, Arłukowicz Elzbieta, Sledzińska Anna, Bolewska Beata
Katedra i Klinika Chorób Zakaźnych AM w Poznaniu.
Przegl Epidemiol. 2006;60(1):7-15.
Evaluation the value of procalcitonin as a diagnostic and prognostic marker in septic patients and patients with systemic inflammatory response syndrome (SIRS).
126 patients were included into the study. The patients were divided into four groups: 1--septic patients with positive blood cultures, 2--septic patients with negative blood cultures, 3--patients with SIRS, 4--patients without sepsis and SIRS. PCT level was measured by imunoluminometric assay (LUMItest) and immunochromatographic assay (PCT-Q).
PCT level is higher in patients with sepsis than in patients with SIRS. PCT level is only slightly elevated in patients without sepsis and SIRS. The highest PCT level is found in patients with septic shock. In patients with the clinical improvement the frequency of PCT level increase is approximately twice lower than in patients who died.
Measurement of PCT level on the first, second and third day of hospitalization has no prognostic value. There is no significant difference in PCT level in sepsis caused by Gram positive and Gram negative bacteria. PCT is a useful marker in diagnosis of sepsis but its role in monitoring the severity of sepsis requires more clinical studies.
评估降钙素原作为脓毒症患者及全身炎症反应综合征（SIRS）患者诊断和预后标志物的价值。
126例患者纳入本研究。患者分为四组：1组——血培养阳性的脓毒症患者；2组——血培养阴性的脓毒症患者；3组——SIRS患者；4组——无脓毒症和SIRS的患者。采用免疫发光分析法（LUMItest）和免疫层析法（PCT-Q）测定降钙素原水平。
脓毒症患者的降钙素原水平高于SIRS患者。无脓毒症和SIRS的患者降钙素原水平仅略有升高。脓毒性休克患者的降钙素原水平最高。临床症状改善的患者降钙素原水平升高的频率约为死亡患者的一半。
住院第1、2、3天测定降钙素原水平无预后价值。革兰氏阳性菌和革兰氏阴性菌所致脓毒症患者的降钙素原水平无显著差异。降钙素原是脓毒症诊断的有用标志物，但其在监测脓毒症严重程度方面的作用需要更多临床研究。
