Matłosz Bartłomiej, Durlik Magdalena
Klinika Medycyny Transplantacyjnej i Nefrologii, Instytut Transplantologii Akademii Medycznej w Warszawie.
Przegl Epidemiol. 2006;60(1):133-40.
Polyomavirus BK (BKV) infection is a fast growing problem in modern transplantation medicine. Interstitial nephritis is the most important pathology caused by the virus leading to graft failure and the need for dialysis treatment. Ethiopathogenesis of the disease is multifactorial with immunosuppressive treatment playing main role. Many cases of BKV infection have been misdiagnosed and mistreated as steroid-resistant acute rejection. In such cases the infection was spreading what inevitably led to graft failure. Now it is known that the only way to control the disease is close monitoring and decreasing the net state of immunosuppression.
多瘤病毒BK（BKV）感染在现代移植医学中是一个快速增长的问题。间质性肾炎是该病毒引起的最重要病理改变，可导致移植肾失功并需要透析治疗。该疾病的发病机制是多因素的，免疫抑制治疗起主要作用。许多BKV感染病例被误诊和误治为激素抵抗性急性排斥反应。在这些病例中，感染不断扩散，不可避免地导致移植肾失功。现在已知控制该疾病的唯一方法是密切监测并降低免疫抑制的净状态。
