[氯化镓对维甲酸诱导的骨质疏松大鼠模型的动态影响]
[Dynamic effects of gallium chloride on osteoporotic rat model induced by tretinoin].
作者信息
Dai Xiao-xia, Xiong Yong-min, Guo Xiong, Xue Li
机构信息
Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education, Medical School of Xi'an Jiaotong University, Xi'an 710061, China.
出版信息
Wei Sheng Yan Jiu. 2006 Mar;35(2):175-8.
OBJECTIVE
To investigate the effect of gallium salts on bone metabolism in osteoporosis rats caused by tretinoin.
METHODS
After duplicating osteoporotic model of rats by using tretinoin, we observed the metabolism of blood, urine and bone in vivo. The rats were divided into control group, osteoporosis group, estrogen treated and gallium chloride treated group. The indexes of bone metabolism and related indexes in serum and urine were observed after 60 days of treatment. In the same time, we observed the dynamic effect of 30 days and 60 days of treatment.
RESULTS
After duplicating osteoporotic model, rats' bone structures were injured, the bone mineral density and the organic matrix decreased, the contents of tartrate-resistant acid phosphatase (TRAP) in serum were higher. After gallium salt treating, the above damages were inhibited or retarded. Trabecular width and thickness of bone cortex were significantly increased. AKP and TRAP activities were decreased to the level close to that of the control group.
CONCLUSION
Gallium salt is effective in treating osteoporosis.
目的
探讨镓盐对维甲酸所致骨质疏松大鼠骨代谢的影响。
方法
采用维甲酸复制大鼠骨质疏松模型后，观察体内血液、尿液及骨代谢情况。将大鼠分为对照组、骨质疏松组、雌激素治疗组和氯化镓治疗组。治疗60天后观察骨代谢指标及血清和尿液中的相关指标。同时，观察治疗30天和60天的动态效果。
结果
复制骨质疏松模型后，大鼠骨结构受损，骨密度和有机基质降低，血清中抗酒石酸酸性磷酸酶（TRAP）含量升高。经镓盐治疗后，上述损伤得到抑制或延缓。骨小梁宽度和骨皮质厚度明显增加。碱性磷酸酶（AKP）和TRAP活性降至接近对照组水平。
结论
镓盐对治疗骨质疏松有效。
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