[Design, synthesis and insulin-sensitizing activity of indole derivatives].

AIM

To design and synthesize compounds with insulin-sensitizing activity.

METHODS

Using association principle of drug design, ten title compounds were designed and synthesized on the basis of known compounds with insulin-sensitizing activity, and their insulin-sensitizing activity were evaluated on 3T3-L1 pre-adipocyte cells.

RESULTS

One of the synthesized compounds showed strong insulin-sensitizing activity in vitro.

CONCLUSION

This compound may possess good sugar-lowering activity, and will be chosen for further hypoglycemic evaluation in vivo.