Tang Lei, Yang Yu-she, Ji Ru-yun
School of Pharmacy, Guiyang Medical College, China.
Yao Xue Xue Bao. 2006 Mar;41(3):225-9.
To design and synthesize compounds with insulin-sensitizing activity.
Using association principle of drug design, ten title compounds were designed and synthesized on the basis of known compounds with insulin-sensitizing activity, and their insulin-sensitizing activity were evaluated on 3T3-L1 pre-adipocyte cells.
One of the synthesized compounds showed strong insulin-sensitizing activity in vitro.
This compound may possess good sugar-lowering activity, and will be chosen for further hypoglycemic evaluation in vivo.
设计并合成具有胰岛素增敏活性的化合物。
利用药物设计的关联原理，在已知具有胰岛素增敏活性的化合物基础上设计并合成了10个目标化合物，并在3T3-L1前脂肪细胞上评价了它们的胰岛素增敏活性。
合成的化合物之一在体外表现出较强的胰岛素增敏活性。
该化合物可能具有良好的降糖活性，将被选作进一步的体内降糖评价。
