Murphy S M, Tyrer P
St. Thomas's Hospital, London.
Br J Psychiatry. 1991 Apr;158:511-6. doi: 10.1192/bjp.158.4.511.
Using a double-blind procedure, 68 patients with putative benzodiazepine dependence were randomly allocated to one of three groups given lorazepam (n = 22), diazepam (n = 23) or bromazepam (n = 23) in doses equivalent to those of the patients' original benzodiazepine. After four weeks the dosage was reduced in 25% quantities until no further benzodiazepines were taken. A total of 23 patients dropped out during the study, ten on lorazepam (one of whom committed suicide), seven on diazepam and six on bromazepam. There were few differences in withdrawal symptoms between the three groups but, despite the higher dropout rate, these symptoms were somewhat less marked in the lorazepam group. Withdrawal symptoms were greater in patients who had taken a benzodiazepine for greater than 5 years and were most marked in those with personality disorders, predominantly dependent ones.
采用双盲程序，将68例疑似苯二氮䓬类药物依赖患者随机分为三组，分别给予与患者原服用苯二氮䓬类药物剂量相当的劳拉西泮（n = 22）、地西泮（n = 23）或溴西泮（n = 23）。四周后，剂量以25%的幅度递减，直至不再服用苯二氮䓬类药物。研究期间共有23例患者退出，其中10例服用劳拉西泮（其中1例自杀），7例服用地西泮，6例服用溴西泮。三组之间戒断症状差异不大，但尽管退出率较高，劳拉西泮组的这些症状略显轻微。服用苯二氮䓬类药物超过5年的患者戒断症状更严重，在人格障碍患者中最为明显，主要是依赖型人格障碍患者。
