摇头丸：进一步证明其在内侧前额叶皮质的作用是由血清素能系统介导的。
MDMA: further evidence that its action in the medial prefrontal cortex is mediated by the serotonergic system.
作者信息
Pan H S, Wang R Y
机构信息
Department of Psychiatry and Behavioral Science, State University of New York, Stony Brook 11794.
出版信息
Brain Res. 1991 Jan 25;539(2):332-6. doi: 10.1016/0006-8993(91)91640-m.
Systemically administered (+/-)-MDMA (3,4-methylenedioxymethamphetamine, 'Ecstasy') suppressed the firing rates of the majority of neurons in the medial prefrontal cortex (mPFc). The responses of mPFc cells to (+/-)-MDMA is mimicked by (+)-MDMA but not (-)-MDMA. Furthermore, pretreatment with fluoxetine (a specific 5-HT uptake blocker) but not GBR 12909 (a specific dopamine uptake blocker) prevented the suppressant action of MDMA. These data support the notion that the 5-HT system mediates (+/-)-MDMA's action.
全身给药的（±）-3,4-亚甲基二氧甲基苯丙胺（摇头丸）抑制了内侧前额叶皮质（mPFc）中大多数神经元的放电频率。mPFc细胞对（±）-摇头丸的反应可被（+）-摇头丸模拟，但不能被（-）-摇头丸模拟。此外，用氟西汀（一种特异性5-羟色胺摄取阻滞剂）预处理可阻止摇头丸的抑制作用，但用GBR 12909（一种特异性多巴胺摄取阻滞剂）预处理则不能。这些数据支持5-羟色胺系统介导（±）-摇头丸作用的观点。
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