Dougherty P M, Willis W D
Department of Anatomy and Neurosciences, University of Texas Medical Branch, Galveston 77550-2772.
Brain Res. 1991 Feb 22;542(1):15-22. doi: 10.1016/0006-8993(91)90991-4.
Excitatory amino acids (EAAs) are likely to play a key role in sensory transmission in the spinal cord. In the present study, the microiontophoresis technique was used to investigate the effects of L-glutamate (GLUT), N-methyl-D-aspartate (NMDA), and quisqualate (QUIS), as well as an NMDA receptor antagonist, AP-7, on the discharges evoked in nociceptive primate spinothalamic tract (STT) neurons by mechanical stimulation of the skin. Responses to innocuous brushing of the skin were facilitated by GLUT and NMDA (and in some neurons by QUIS) and sometimes reduced by AP-7. GLUT also facilitated the responses to noxious mechanical stimuli. The results are consistent with anatomical evidence for the presence of synapses that contain EAAs on primate STT cells and with the proposal that the co-release of EAAs and neuropeptides may contribute to hyperalgesia.
兴奋性氨基酸（EAAs）可能在脊髓感觉传导中起关键作用。在本研究中，采用微量离子电泳技术研究了L-谷氨酸（GLUT）、N-甲基-D-天冬氨酸（NMDA）和quisqualate（QUIS）以及NMDA受体拮抗剂AP-7对机械刺激皮肤在伤害性灵长类动物脊髓丘脑束（STT）神经元中诱发放电的影响。GLUT和NMDA（在一些神经元中QUIS也有作用）可促进对皮肤无害轻刷的反应，而AP-7有时会减弱这种反应。GLUT还可促进对有害机械刺激的反应。这些结果与在灵长类动物STT细胞上存在含有EAAs的突触的解剖学证据一致，也与EAAs和神经肽共同释放可能导致痛觉过敏的观点一致。
