El Alwani Mazen, Wu Bill Xingjun, Obeid Lina M, Hannun Yusuf A
Department of Medicine, Division of General Internal Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
Pharmacol Ther. 2006 Oct;112(1):171-83. doi: 10.1016/j.pharmthera.2006.04.004. Epub 2006 Jun 8.
Inflammation is viewed as a protective response against insults to the organism. It involves the recruitment of many cell types and the production of various inflammatory mediators in attempts to contain and reverse the insult. However, inflammation can lead to irreversible tissue destruction by itself and, therefore, can represent a disease state that causes significant morbidity and mortality. Understanding the molecular mechanisms controlling the inflammatory response is essential to formulate therapeutic strategies for the treatment of inflammatory conditions. In fact, substantial research has unveiled important aspects of the inflammatory machinery, both at the cellular and molecular levels. Recently, sphingolipids (SLs) have emerged as signaling molecules that regulate many cell functions, and ample evidence emphasizes their role in the regulation of inflammatory responses. Here, we review the role of bioactive SL as regulators and mediators of inflammatory responses.
炎症被视为机体对损伤的一种保护性反应。它涉及多种细胞类型的募集以及各种炎症介质的产生，旨在控制并扭转损伤。然而，炎症本身可导致不可逆的组织破坏，因此可能代表一种引发显著发病率和死亡率的疾病状态。了解控制炎症反应的分子机制对于制定治疗炎症性疾病的策略至关重要。事实上，大量研究已揭示了炎症机制在细胞和分子水平的重要方面。最近，鞘脂类（SLs）已成为调节多种细胞功能的信号分子，大量证据强调了它们在调节炎症反应中的作用。在此，我们综述生物活性鞘脂类作为炎症反应调节剂和介质的作用。
