Paul Lynn K, Lautzenhiser Aaron, Brown Warren S, Hart Arch, Neumann Dirk, Spezio Michael, Adolphs Ralph
California Institute of Technology, Division of Humanities and Social Sciences, CA 91125, USA.
Int J Psychophysiol. 2006 Jul;61(1):47-56. doi: 10.1016/j.ijpsycho.2005.10.017. Epub 2006 Jun 6.
While the processing of verbal and psychophysiological indices of emotional arousal have been investigated extensively in relation to the left and right cerebral hemispheres, it remains poorly understood how both hemispheres normally function together to generate emotional responses to stimuli. Drawing on a unique sample of nine high-functioning subjects with complete agenesis of the corpus callosum (AgCC), we investigated this issue using standardized emotional visual stimuli. Compared to healthy controls, subjects with AgCC showed a larger variance in their cognitive ratings of valence and arousal, and an insensitivity to the emotion category of the stimuli, especially for negatively-valenced stimuli, and especially for their arousal. Despite their impaired cognitive ratings of arousal, some subjects with AgCC showed large skin-conductance responses, and in general skin-conductance responses discriminated emotion categories and correlated with stimulus arousal ratings. We suggest that largely intact right hemisphere mechanisms can support psychophysiological emotional responses, but that the lack of interhemispheric communication between the hemispheres, perhaps together with dysfunction of the anterior cingulate cortex, interferes with normal verbal ratings of arousal, a mechanism in line with some models of alexithymia.
虽然言语和情绪唤起的心理生理指标的处理已经在与左右脑半球的关系中得到了广泛研究，但对于两个半球如何正常协同工作以产生对刺激的情绪反应，人们仍然知之甚少。利用九名胼胝体完全发育不全（AgCC）的高功能受试者的独特样本，我们使用标准化的情绪视觉刺激来研究这个问题。与健康对照组相比，AgCC受试者在效价和唤起的认知评分上表现出更大的差异，并且对刺激的情绪类别不敏感，尤其是对负性效价的刺激，特别是对其唤起方面。尽管他们对唤起的认知评分受损，但一些AgCC受试者表现出较大的皮肤电反应，总体而言，皮肤电反应能够区分情绪类别并与刺激唤起评分相关。我们认为，大体完整的右半球机制可以支持心理生理情绪反应，但半球间缺乏半球间通信，可能与前扣带回皮质功能障碍一起，干扰了对唤起的正常言语评分，这一机制与一些述情障碍模型一致。
