新型5-取代靛玉红作为蛋白激酶抑制剂的合成
Synthesis of novel 5-substituted indirubins as protein kinases inhibitors.
作者信息
Beauchard Anne, Ferandin Yoan, Frère Stéphane, Lozach Olivier, Blairvacq Mélina, Meijer Laurent, Thiéry Valérie, Besson Thierry
机构信息
Laboratoire de Biotechnologies et de Chimie Bio-organique, FRE CNRS 2766, UFR Sciences Fondamentales et Sciences pour l'Ingénieur, Université de La Rochelle, Bâtiment Marie Curie, 17042 La Rochelle, France.
出版信息
Bioorg Med Chem. 2006 Sep 15;14(18):6434-43. doi: 10.1016/j.bmc.2006.05.036. Epub 2006 Jun 8.
In an effort to identify new pharmacological inhibitors of disease-relevant protein kinases with increased potency and selectivity, we synthesized and evaluated new 5-substituted indirubins. The effects of 34 indirubin derivatives on CDK1/cyclin B, CDK5/p25, and GSK-3, as well as on SH-SY5Y human neuroblastoma cell survival, were investigated.
为了寻找效力和选择性更高的与疾病相关的蛋白激酶新的药理抑制剂，我们合成并评估了新型5-取代靛玉红。研究了34种靛玉红衍生物对CDK1/细胞周期蛋白B、CDK5/p25和GSK-3的影响，以及对SH-SY5Y人神经母细胞瘤细胞存活的影响。
Zotero 插件