Dugernier Th, Dewaele J, Laterre P F
Department of Intensive Care and Emergency Medicine, St Luc University Hospital, Brussels, Belgium.
Acta Chir Belg. 2006 Mar-Apr;106(2):165-71. doi: 10.1080/00015458.2006.11679864.
About 20% of the patients with acute pancreatitis may run a rapidly progressive or fulminant course resulting in the multiple organ dysfunction syndrome with or without accompanying sepsis. In this subset of patients, the mortality rate still ranges from less than 10% with sterile to over 30% with infected pancreatic necrosis. The goal of this review is to assess the available treatment strategies to allow the development of a formalized surgical approach to those patients.
A literature review of management of acute pancreatitis.
Over the past 20 years, there has been a substantial change in the surgical management of severe acute pancreatitis. This change has been away from a preventive surgery based on early major interventions towards a surgery of complications based increasingly on less aggressive options that take place at a later stage of the attack with specific criteria governing the timing of surgical therapy. Non-surgical options remain more than ever the cornerstone of management in many of these patients.
约20%的急性胰腺炎患者可能会经历快速进展或暴发性病程,导致多器官功能障碍综合征,伴或不伴有脓毒症。在这部分患者中,无菌性胰腺坏死的死亡率仍低于10%,而感染性胰腺坏死的死亡率超过30%。本综述的目的是评估现有的治疗策略,以便为这些患者制定规范化的手术方法。
对急性胰腺炎治疗的文献进行综述。
在过去20年中,重症急性胰腺炎的手术治疗发生了重大变化。这种变化已从基于早期重大干预的预防性手术,转向越来越基于不太激进的选择的并发症手术,这些选择在疾病发作后期进行,并遵循特定的手术治疗时机标准。在许多此类患者中,非手术选择仍然是治疗的基石。